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Chemical Senses 2: 63-69,
© 1976

research-article

OFF-RESPONSE OF GUSTATORY NERVE FOLLOWING TERMINATION OF QUININE STIMULI APPLIED TO THE FROG TONGUE

TOSHIHIDE SATO

Dep. of Physiology, School of Dentistry, Tokyo Medical and Dental University Bunkyo-ku, Tokyo, Japan

After a Ringer-adapted frog tongue was stimulated with 0.001 M quinine-HCl(Q-HCl) in deionized water, the Ringer rinse of the tongue elicited a large gustatory nerve response. Since the Ringer-adapted tongue did not respond to Ringer solution, this nerve response after Q-HC1 is termed an off-response. It was revealed that the off-response of gustatory nerve to the Ringer rinse resulted from the enhancing effect of Q-HCl adaptation upon the response to 111.2 mM NaCl component of Ringer which was ineffective for Ringer-adapted tongue. Weaker enhancement of the response to NaCl of Ringer was also produced by adapting the tongue to water. Therefore, the enhancing effect of Q-HCl in deionized water is the summed effect of Q-HCl solute and water solvent. Microelectrode study revealed that during the adaptation to Q-HCl the membrance potential of some NaCl-sensitive taste cells was more hyperpolarized than that of Ringer-adapted state. The larger membrane potential maintained under Q-HCl adaptation was markedly depolarized by the NaCl component of the Ringer. This sufficient depolarization response of the taste cells might be associated with generation of the off-response in the gustatory nerve.


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