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Chemical Senses 21: 159-168,
© 1996

research-article

Induction of a Calcium-dependent Long-term Enhancement of Excitability in the Rat Olfactory Bulb

Abdelkrim Elaagouby1 and Rémi Gervais

Laboratoire de Physiologie Neurosensorielle, Université Claude Bernard-Lyon 1 CNRS URA 180, F-69622 Villeurbanne cédex, France

We have investigated whether a transient increase in extracellular calcium concentration is able to induce long-term modification of neuronal excitability in the olfactory bulb. High-calcium artificial cerebrospinal fluid containing picrotoxin (Ca-PTX solution) was applied locally near the mitral cell layer through a push-pull device for 10 min in anaesthetized rats. Changes in the neuronal excitability were monitored through electrically-evoked field potentials. Application of the Ca-PTX solution induced a rapid increase in the granule cell response amplitude, whereas mitral/tufted cells response amplitude increased more progressively and reached its maximum within a few hours. The increase in mitral/tufted cells response and granule cells response reached between 30 and 100% in experiments which lasted for 4–8 h. Pre-application of amino-phosphonovalerate (NMDA receptor blocker) potently reduced both short- and long-term enhancement produced by the Ca-PTX solution. Neither application of the high calcium solution alone nor the picrotoxin solution alone induced long-term changes. The results point out the possible importance of Ca2+ and NMDA receptors in persistent forms of olfactory bulb plasticity. Relevance of this phenomenon in normal olfactory bulb physiology remains to be examined. Chem. Senses 21: 159–168, 1996.

1Present address: California Institute of Technology, Division of Biology 216-76, Pasadena, CA 91125, USA


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