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Chemical Senses 21: 181-188,
© 1996

research-article

45-KDa GTP-binding Protein from Rat Olfactory Epithelium: Purification, Characterization and Localization

V.I. Novoselov, I.V. Peshenko, V.A. Evdokimov, J.V. Nikolaev, E.A. Matveeva and E.E. Fesenko

Institute of Cell Biophysics, Russian Academy of Sciences Pushchino, Moscow Region, Russia

Correspondence to be sent to: V.I. Novoselov, Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142292, Russia

The rat olfactory epithelium contains a specific water-soluble 45-kDa protein. This protein is recognized by anti-peptide antibodies which react with {alpha}-subunits of the known G-proteins. The 45-kDa protein has been isolated using DEAE-chromatography and gel-exclusion chromatography. The content of 45-kDa protein is about 2% of the total soluble proteins of the olfactory mucosa and it is located at the mucociliary surface. According to photo-affinity labeling, the 45-kDa protein possesses a high affinity to GTP and exhibits low GTP hydrolytic activity. The functions of the 45-kDa protein are discussed. Chem, Senses 21: 181–188, 1996.


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