Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (20)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Dulac, C.
Right arrow Articles by Axel, R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Dulac, C.
Right arrow Articles by Axel, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Chemical Senses 23: 467-475,
© 1998 Oxford University Press

Expression of Candidate Pheromone Receptor Genes in Vomeronasal Neurons

Catherine Dulac1 and Richard Axel2

1 Howard Hughes Medical Institute, and Department of Molecular and Cellular Biology, Harvard University Cambridge, MA 2 Howard Hughes Medical Institute, and Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University New York, NY, USA

Catherine Dulac, Blo. Labs 415, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA. e-mail: dulac{at}fas.harvard.edu


  Abstract

In mammals, olfactory sensory perception is mediated by two anatomically and functionally distinct organs: the main olfactory epithelium (MOE) and the vomeronasal organ (VON). Pheromones activate the VNO and elicit a characteristic array of innate reproductive and social behaviors, along with dramatic neuroendocrine responses. Recent approaches have provided new insights into the molecular biology of sensory transduction in the VNO. Differential screening of cDNA libraries constructed from single sensory neurons from the rat VNO has led to the isolation of a family of genes which are likely to encode mammalian pheromone receptors. The isolation of these receptors from the VNO might permit the analysis of the molecular events which translate the bindings of pheromones into innate stereotypic behaviors and help to elucidate the logic of pheromone perception in mammals.

Accepted 18 March 1997


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Chem SensesHome page
H. Kouros-Mehr, S. Pintchovski, J. Melnyk, Y.-J. Chen, C. Friedman, B. Trask, and H. Shizuya
Identification of Non-functional Human VNO Receptor Genes Provides Evidence for Vestigiality of the Human VNO
Chem Senses, November 1, 2001; 26(9): 1167 - 1174.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
P. Duchamp-Viret, M. A. Chaput, and A. Duchamp
Odor Response Properties of Rat Olfactory Receptor Neurons
Science, June 25, 1999; 284(5423): 2171 - 2174.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.