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Chem. Senses 24: 37-46, 1998
© Oxford University Press

NMDA and non-NMDA Receptors Mediate Responses in the Primary Gustatory Nucleus in Goldfish

Cynthia A. Smeraski, Thomas V. Dunwiddie1, Lihong Diao1 and Thomas E. Finger

Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, CO 80262, USA 1 Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA

Correspondence to be sent to: Dr Cynthia A. Smeraski, Department of Cellular and Structural Biology, Campus Box B111, University of Colorado Health Sciences Center, 4200 E. Ninth Ave., Denver, CO 80262, USA

Primary gustatory afferents from the oropharynx of the goldfish, Carassius auratus, terminate in the vagal lobe, a laminated structure in the dorsal medulla comparable to the gustatory portion of the nucleus of the solitary tract in mammals. We utilized an in vitro brain slice preparation to test the role of different ionotropic glutamate receptor subtypes in synaptic transmission of gustatory information by recording changes in field potentials after application of various glutamate receptor antagonists. Electrical stimulation of the vagus nerve (NX) evokes two short-latency postsynaptic field potentials from sensory layers of the vagal lobe. 6,7-Dinitroquinoxaline-2,3-dione and 6-nitro-7-sulphamoylbenzo[f]quinoxaline-2,3-dione, two non-N-methyl-D-aspartate (NMDA) ionotropic receptor antagonists, blocked these short-latency potentials. Slower potentials that were revealed under Mg2+-free conditions, were abolished by the NMDA receptor antagonist, D(–)-2-amino-5-phosphonovaleric acid (APV). Repetitive stimulation produced short-term facilitation, which was attenuated by application of APV. These results indicate that the synaptic responses in the vagal lobe produced by stimulation of the gustatory roots of the NX involve both NMDA and non-NMDA receptors. An NMDA receptor-mediated facilitation may serve to amplify incoming bursts of primary afferent activity.


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