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Chem. Senses 24: 289-293, 1999
© Oxford University Press

Induction of Estrus in Grouped Female Mice (Mus domesticus) by Synthetic Analogues of Preputial Gland Constituents

Weidong Ma, Zhongshan Miao and Milos V. Novotny

Department of Chemistry, Indiana University, Bloomington, IN 47405, USA

Correspondence to be sent to: Milos V. Novotny, Department of Chemistry, Indiana University, Bloomington, IN 47405, USA. e-mail:novotny{at}indiana.edu

Two major volatile constituents of the male mouse preputial gland, E,E-{alpha}-farnesene and E-ß-farnesene, were examined for their role in inducing estrous cycles in grouped female mice. The results indicated that the mixture of the farnesenes was as effective as the homogenate of the intact preputial gland, while the extract of the castrate preputial tissue did not show a pronounced response.


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