Chem. Senses 26: 471-482,
2001
© Oxford University Press 2001
Hemispheric Dominance of Cortical Activity Evoked by Focal Electrogustatory Stimuli
Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030-3705 and 1 Department of Diagnostic Radiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
Correspondence to be sent to: Michael A. Barry, Department of BioStructure and Function, University of Connecticut Health Center, Farmington, CT 06030-3705, USA
Functional magnetic resonance imaging was used to observe cortical hemodynamic responses to electric taste stimuli applied separately to the right and left sides of the tongue tip. In 11 right-handed normal adults activation occurred primarily in the insular cortex, superior temporal lobe, inferior frontal lobe, including premotor regions, and in inferior parts of the postcentral gyrus. Unexpectedly, the location and laterality of activation were largely identical regardless of the side of the tongue stimulated. Activation in the superior insula, the presumed location of primary gustatory cortex, was predominantly, but not exclusively, in the right hemisphere, whereas central (more inferior) insular activations were more evenly bilateral. Right hemispheric dominance of activation also occurred in premotor regions (Brodmann areas 6 and 44), whereas left hemispheric dominance occurred only in the superior temporal cortex (Brodmann areas 22/42). The electric taste-evoked hemodynamic response pattern was more consistent with activation of the gustatory system than activation of somatosensory systems. The results suggest that the sites for cortical processing of electric taste information are dependent on hemispheric specialization.
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