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Chem. Senses 26: 517-522, 2001
© Oxford University Press 2001

Vomeronasal Epithelial Cells of Human Fetuses Contain Immunoreactivity for G Proteins, Go{alpha} and Gi{alpha}2

Shigeru Takami, Maiko Yukimatsu, George Matsumura1 and Fumiaki Nishiyama

Department of Anatomy, School of Health Sciences, Kyorin University, Hachioji, Tokyo 192-8508 and 1 Department of Anatomy, School of Medicine, Kyorin University, Mitaka, Tokyo 181-8611, Japan

Correspondence to be sent to: S. Takami, Department of Anatomy, School of Health Sciences, Kyorin University, 476 Miyashita, Hachioji, Tokyo 192-8508, Japan. e-mail: takamis{at}kyorin-u.ac.jp

Two G protein subfamilies, Go{alpha} and Gi{alpha}2, were identified and localized immunohistochemically in the vomeronasal organ (VNO) of 5-month-old human fetuses. Immunoreactivity for Go{alpha} and Gi{alpha}2 was present in a subset of vomeronasal epithelial cells. Prominent immunoreactivity was observed in apical processes and their apical terminals facing onto the vomeronasal lumen. Nerve fibers associated with the VNO exhibited intense immunoreactivity for Go{alpha} and weak immunoreactivity for Gi{alpha}2. Since Go{alpha} and Gi{alpha}2 are characteristically expressed and coupled with putative pheromone receptors in rodent vomeronasal receptor neurons, the present results suggest the possibility that vomeronasal epithelial cells containing Go{alpha} and Gi{alpha}2 in human fetuses are chemosensory neurons.


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