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Chem. Senses 26: 663-672, 2001
© Oxford University Press 2001

A Simple and Reliable Test of Olfactory Learning and Memory in Mice

Heather M. Schellinck, Catherine A. Forestell and Vincent M. LoLordo

Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada

Correspondence to be sent to: Heather Schellinck, Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada. e-mail: heathers{at}is.dal.ca

The present paper describes a quick and efficient method for assessing olfactory discrimination learning in mice. In training mice received trials in which one odor (CS+) was paired with sugar and another odor (CS–) was paired with no sugar. When the mice were subsequently placed in a chamber with CS+ odor at one end and CS– odor at the other, they spent more time digging in CS+ than in CS– odor. In Experiment 2 mice trained with this procedure and tested after 60 days also spent more time digging in CS+ than CS– in the test phase, indicating that this olfactory discrimination task is effective for assessing long-term memory. In addition to the outbred strain of CD1 mice used in Experiments 1 and 2, C57Bl/6NCr/BR and DBA/2NCr/BR mice used in Experiment 3 also acquired this learned odor discrimination. Moreover, Experiment 4 showed that DBA animals were capable of acquiring this odor discrimination after receiving only two training trials (one exposure each to CS+ and CS–) per day for 4 days.


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