Chem. Senses 26: 905-913,
2001
© Oxford University Press 2001
Sweetener Preference of C57BL/6ByJ and 129P3/J Mice
Monell Chemical Senses Center, Philadelphia, PA 19104, USA
Correspondence to be sent to: Alexander A. Bachmanov, Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA. e-mail: bachmanov{at}monell.org
Previous studies have shown large differences in taste responses to several sweeteners between mice of the C57BL/6ByJ (B6) and 129P3/J (129) inbred strains. The goal of this study was to compare behavioral responses of B6 and 129 mice to a wider variety of sweeteners. Seventeen sweeteners were tested using two-bottle preference tests with water. Three main patterns of strain differences were evident. First, sucrose, maltose, saccharin, acesulfame-K, sucralose and SC-45647 were preferred by both strains, but the B6 mice had lower preference thresholds and higher solution intakes. Second, the amino acids D-phenylalanine, D-tryptophan, L-proline and glycine were highly preferred by B6 mice, but not by 129 mice. Third, glycyrrhizic acid, neohesperidin dihydrochalcone, thaumatin and cyclamate did not evoke strong preferences in either strain. Aspartame was neutral to all 129 and some B6 mice, but other B6 mice strongly preferred it. Thus, compared with the 129 mice the B6 mice had higher preferences for sugars, sweet tasting amino acids and several but not all non-caloric sweeteners. Glycyrrhizic acid, neohesperidin, thaumatin and cyclamate are not palatable to B6 or 129 mice.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Jiang, G. Blonde, M. Garcea, and A. C. Spector Greater Superficial Petrosal Nerve Transection in Rats does not Change Unconditioned Licking Responses to Putatively Sweet Taste Stimuli Chem Senses, July 31, 2008; (2008) bjn039v3. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Gordesky-Gold, N. Rivers, O. M. Ahmed, and P. A.S. Breslin Drosophila melanogaster Prefers Compounds Perceived Sweet by Humans Chem Senses, March 1, 2008; 33(3): 301 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Inoue, J. I. Glendinning, M. L. Theodorides, S. Harkness, X. Li, N. Bosak, G. K. Beauchamp, and A. A. Bachmanov Allelic variation of the Tas1r3 taste receptor gene selectively affects taste responses to sweeteners: evidence from 129.B6-Tas1r3 congenic mice Physiol Genomics, December 19, 2007; 32(1): 82 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ji and A. A. Bachmanov Differences in postingestive metabolism of glutamate and glycine between C57BL/6ByJ and 129P3/J mice Physiol Genomics, November 14, 2007; 31(3): 475 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Dotson and A. C. Spector Behavioral Discrimination between Sucrose and Other Natural Sweeteners in Mice: Implications for the Neural Coding of T1R Ligands J. Neurosci., October 17, 2007; 27(42): 11242 - 11253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Tordoff Taste Solution Preferences of C57BL/6J and 129X1/SvJ Mice: Influence of Age, Sex, and Diet Chem Senses, September 1, 2007; 32(7): 655 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Keskitalo, A. Knaapila, M. Kallela, A. Palotie, M. Wessman, S. Sammalisto, L. Peltonen, H. Tuorila, and M. Perola Sweet taste preferences are partly genetically determined: identification of a trait locus on chromosome 16 Am. J. Clinical Nutrition, July 1, 2007; 86(1): 55 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sclafani, L. Rinaman, R. R. Vollmer, and J. A. Amico Oxytocin knockout mice demonstrate enhanced intake of sweet and nonsweet carbohydrate solutions Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1828 - R1833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Palmer The Pharmacology and Signaling of Bitter, Sweet, and Umami Taste Sensing Mol. Interv., April 1, 2007; 7(2): 87 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. McCaughey Taste-Evoked Responses to Sweeteners in the Nucleus of the Solitary Tract Differ between C57BL/6ByJ and 129P3/J Mice J. Neurosci., January 3, 2007; 27(1): 35 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Manita, A. A. Bachmanov, X. Li, G. K. Beauchamp, and M. Inoue Is Glycine "Sweet" to Mice? Mouse Strain Differences in Perception of Glycine Taste Chem Senses, November 1, 2006; 31(9): 785 - 793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nie, J. R. Hobbs, S. Vigues, W. J. Olson, G. L. Conn, and S. D. Munger Expression and Purification of Functional Ligand-Binding Domains of T1R3 Taste Receptors Chem Senses, July 1, 2006; 31(6): 505 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.R. Delay, N.P. Hernandez, K. Bromley, and R.F. Margolskee Sucrose and Monosodium Glutamate Taste Thresholds and Discrimination Ability of T1R3 Knockout Mice Chem Senses, May 1, 2006; 31(4): 351 - 357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. DeFazio, G. Dvoryanchikov, Y. Maruyama, J. W. Kim, E. Pereira, S. D. Roper, and N. Chaudhari Separate Populations of Receptor Cells and Presynaptic Cells in Mouse Taste Buds J. Neurosci., April 12, 2006; 26(15): 3971 - 3980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Damak, M. Rong, K. Yasumatsu, Z. Kokrashvili, C. A. Perez, N. Shigemura, R. Yoshida, B. Mosinger Jr., J. I. Glendinning, Y. Ninomiya, et al. Trpm5 Null Mice Respond to Bitter, Sweet, and Umami Compounds Chem Senses, March 1, 2006; 31(3): 253 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Jiang, M. Cui, B. Zhao, L. A. Snyder, L. M. J. Benard, R. Osman, M. Max, and R. F. Margolskee Identification of the Cyclamate Interaction Site within the Transmembrane Domain of the Human Sweet Taste Receptor Subunit T1R3 J. Biol. Chem., October 7, 2005; 280(40): 34296 - 34305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Glendinning, S. Chyou, I. Lin, M. Onishi, P. Patel, and K. H. Zheng Initial Licking Responses of Mice to Sweeteners: Effects of Tas1r3 Polymorphisms Chem Senses, September 1, 2005; 30(7): 601 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sclafani and J. I. Glendinning Sugar and fat conditioned flavor preferences in C57BL/6J and 129 mice: oral and postoral interactions Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R712 - R720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Glendinning, L. D. Bloom, M. Onishi, K. H. Zheng, S. Damak, R. F. Margolskee, and A. C. Spector Contribution of {alpha}-Gustducin to Taste-guided Licking Responses of Mice Chem Senses, May 1, 2005; 30(4): 299 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Lu, A. H. McDaniel, M. G. Tordoff, X. Li, G. K. Beauchamp, A. A. Bachmanov, D. A. VanderWeele, C. D. Chapman, N. K. Dess, L. Huang, et al. No Relationship between Sequence Variation in Protein Coding Regions of the Tas1r3 Gene and Saccharin Preference in Rats Chem Senses, March 1, 2005; 30(3): 231 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Bachmanov Genetic Approach to Characterize Interaction of Sweeteners with Sweet Taste Receptors In Vivo Chem Senses, January 1, 2005; 30(suppl_1): i82 - i83. [Full Text] [PDF]
|
|
|
|
|
|
S. Eylam and A. C. Spector Stimulus Processing of Glycine is Dissociable from that of Sucrose and Glucose Based on Behaviorally Measured Taste Signal Detection in Sac 'Taster' and 'Non-taster' Mice Chem Senses, September 1, 2004; 29(7): 639 - 649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Danilova and G. Hellekant Sense of Taste in a New World Monkey, the Common Marmoset. II. Link Between Behavior and Nerve Activity J Neurophysiol, August 1, 2004; 92(2): 1067 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Dotson and A. C. Spector The Relative Affective Potency of Glycine, L-Serine and Sucrose as Assessed by a Brief-access Taste Test in Inbred Strains of Mice Chem Senses, July 1, 2004; 29(6): 489 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sclafani and R. A. Clare Female Rats show a Bimodal Preference Response to the Artificial Sweetener Sucralose Chem Senses, July 1, 2004; 29(6): 523 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inoue, D. R. Reed, X. Li, M. G. Tordoff, G. K. Beauchamp, and A. A. Bachmanov Allelic Variation of the Tas1r3 Taste Receptor Gene Selectively Affects Behavioral and Neural Taste Responses to Sweeteners in the F2 Hybrids between C57BL/6ByJ and 129P3/J Mice J. Neurosci., March 3, 2004; 24(9): 2296 - 2303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Cannon and R. D. Palmiter Reward without Dopamine J. Neurosci., November 26, 2003; 23(34): 10827 - 10831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. He, V. Danilova, S. Zou, G. Hellekant, M. Max, R. F. Margolskee, and S. Damak Partial Rescue of Taste Responses of {alpha}-Gustducin Null Mice by Transgenic Expression of {alpha}-Transducin Chem Senses, October 1, 2002; 27(8): 719 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inoue, S. A. McCaughey, A. A. Bachmanov, and G. K. Beauchamp Whole Nerve Chorda Tympani Responses to Sweeteners in C57BL/6ByJ and 129P3/J Mice Chem Senses, September 1, 2001; 26(7): 915 - 923. [Abstract] [Full Text] [PDF]
|
|