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Chem. Senses 26: 1203-1210, 2001
© Oxford University Press 2001

Effects of Amiloride on Gustatory Neural Responses to Salts in the Frog

Yasuyuki Kitada, Kazuhisa Okuda-Akabane and Yoshihiro Mitoh1

Department of Oral Physiology, School of Dentistry, Iwate Medical University, Iwate 020-8505, Japan 1 Department of Oral Physiology, Okayama University Dental School, Okayama 700-8525, Japan

Correspondence to be sent to: Yasuyuki Kitada, Department of Oral Physiology, School of Dentistry, Iwate Medical University, Iwate 020-8505, Japan. e-mail: ykita{at}iwate-med.ac.jp

In frogs, the glossopharyngeal nerve (GL) innervates taste receptors on almost the entire tongue. The mandibular branch (MBF) and palatine branch (PN) of the facial nerve innervate taste receptors on a very small area at the base of the tongue and on the palate, respectively. In the present study, effects of amiloride, an epithelial sodium channel blocker, on the tonic responses of the GL, MBF and PN in frogs to NaCl, LiCl, KCl and CaCl2 were investigated. In three nerves, amiloride at 0.5 mM, a relatively high concentration, did not affect the responses to 0.15 (concentration just above threshold)-0.5 M NaCl, 0.5 M LiCl and 0.3 M KCl, whereas it almost completely inhibited the response to 1.0 mM CaCl2. Amiloride may exert an inhibitory action on the response to CaCl2 by a competitive antagonism between Ca2+ and a monovalent cation of amiloride, because the response to Ca2+ is competitively inhibited by other cations such as Na+ and Mg2+. The lack of inhibitory effect of amiloride on the responses in the GL, MBF and PN to NaCl suggests that amiloride-sensitive sodium channels in the apical membrane of taste receptor cells are not involved in sodium taste transduction in frogs.


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K. Okuda-Akabane, H. Fukami, and Y. Kitada
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Chem Senses, July 1, 2008; 33(6): 523 - 530.
[Abstract] [Full Text] [PDF]


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