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Chem. Senses 27: 577-580, 2002
© Oxford University Press 2002

SYMPOSIUM: Mechanisms of Differentiation and Migration of Olfactory Progenitors

The Progenitor Cells of the Embryonic Telencephalon and the Neonatal Anterior Subventricular Zone Differentially Regulate their Cell Cycle

Marla B. Luskin and Volkan Coskun

Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA

Correspondence to be sent to: Marla B. Luskin, Department of Cell Biology, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael St., Atlanta, GA 30322, USA. e-mail: luskin{at}cellbio.emory.edu

Abstract

For the last 10 years our laboratory has been studying the proliferation, migration and differentiation of neuronal progenitor cells located in the anterior part of the postnatal forebrain subventricular zone (SVZa). SVZa-derived cells possess a number of proliferative characteristics that distinguish them from the other progenitor cells in the central nervous system. This review summarizes our recent findings, in which we compared the pattern of cell cycle inhibitory proteins expressed by the neonatal SVZa to that of telencephalic ventricular zone cells.


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