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Chem. Senses 27: 623-628, 2002
© Oxford University Press 2002

Biopsies of Human Olfactory Epithelium

B.W. Jafek, B. Murrow, R. Michaels, D. Restrepo and M. Linschoten

Rocky Mountain Taste and Smell Center, Denver, CO, USA

Correspondence to be sent to: Bruce W. Jafek, Department of Otolaryngology—Head and Neck Surgery, UCHSC (B-205), 4200 East Ninth Avenue, Denver, CO 80262, USA. e-mail: bruce.jafek{at}uchsc.edu

It has been shown that olfactory epithelium can be safely biopsied from the living, intact human being. Observations of the ultrastructure of this epithelium shows changes that can then be correlated with the etiology and degree of olfactory loss, allowing a greater understanding of both normal transduction and of the pathology of dysfunction. Examples of the common forms of olfactory dysfunction are presented and discussed. Additionally, the technique will allow additional immuno-histochemical and molecular study of the tissue, will increase the understanding of both normal and pathological function and should translate to new therapeutic regimens.


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