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Chem. Senses 27: 711-717, 2002
© Oxford University Press 2002

Potential Changes with Gamma-band Oscillation at the Frontal Scalp Elicited by Intravenous Olfactory Stimulation in Humans

Tadashi Ishimaru1, Sachiko Hatanaka2, Tsuyoshi Yata2, Isao Horikawa1, Toshiaki Tsukatani1, Toshiro Nishimura1, Takaki Miwa1,2 and Mitsuru Furukawa1,2

1 Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Kanazawa University, Kanazawa 920-8641, Japan 2 Division of Neuroscience, Clinical Neuroscience, Graduate School of Medicine, Kanazawa University, Kanazawa 920-8641, Japan

Correspondence to be sent to: Tadashi Ishimaru, Department of Otorhinolaryngology, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. e-mail: ishimar{at}orl.m.kanazawa-u.ac.jp

Intravenous olfaction is a unique stimulation method often used in Japan to diagnose olfactory disturbances. Odorant is injected into a vein and transported by blood flow and respiration to the upper air tract. The intravenous olfaction might allow the potential at the frontal scalp to be recorded without contamination from electromyograms, such as those caused by sniffing. We injected Alinamin (thiamine propyldisulphide) into healthy subjects according to a standard protocol for clinical intravenous olfaction testing and we simultaneously recorded potential changes at the frontal scalp. When Alinamin was injected into the right median cubital vein over a 20 s period, the potential changes with gamma-band oscillations were detected 17.6 ± 6.7 s (mean ± SD) after the start of the injection. The main frequency component of this gamma-band oscillation is 30-160 Hz. The gamma-band oscillation elicited by intravenous olfactory stimulation (VOP) was similar to the induced wave of the olfactory bulb. Mapping the VOPs on the frontal scalp of a subject with less developed frontal sinuses and the relation between the thickness of the frontal sinuses and VOP amplitude suggest an intracranial source, possibly the olfactory bulb. The gamma-band potential at the frontal scalp is a useful measure of central disturbance.


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T. Ishimaru, T. Yata, and S. Hatanaka-Ikeno
Hemodynamic Response of the Frontal Cortex Elicited by Intravenous Thiamine Propyldisulphide Administration
Chem Senses, March 1, 2004; 29(3): 247 - 251.
[Abstract] [Full Text] [PDF]


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