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Chem. Senses 28: 33-43, 2003
© Oxford University Press 2003

The Time Course of Taste Bud Regeneration after Glossopharyngeal or Greater Superficial Petrosal Nerve Transection in Rats

Steven J. St. John1, Mircea Garcea2 and Alan C. Spector2

1 Department of Psychology, Reed College, Portland OR 97202, USA 2 Department of Psychology, Gainesville, FL 32608, USA

Correspondence to be sent to: Steven St. John, Department of Psychology, Reed College, 3203 SE Woodstock Blvd, Portland, OR 97202. e-mail Steven.St.John{at}reed.edu

We previously have published data detailing the time course of taste bud regeneration in the anterior tongue following transection of the chorda tympani (CT) nerve in the rat. This study extends the prior work by determining the time course of taste bud regeneration in the vallate papilla, soft palate and nasoincisor ducts (NID) following transection of either the glossopharyngeal (GL) or greater superficial petrosal (GSP) nerve. Following GL transection in rats (n = 6 per time point), taste buds reappeared in the vallate papilla between 15 and 28 days after surgery, and returned to 80.3% of control levels (n = 12) of taste buds by 70 days postsurgery. The first appearance and the final percentage of the normal complement of regenerated vallate taste buds after GL transection resembled that seen previously in the anterior tongue after CT transection. However, in the latter case, regenerated taste buds reached asymptotic levels by 42 days after surgery, whereas within the time frame of the present study, a clear asymptotic return of vallate taste buds was not observed. In contrast to the posterior (and anterior) tongue, only 25% of the normal complement of palatal taste buds regenerated by 112 days and 224 days after GSP transection (n = 9). The difference in regenerative capacity might relate to the surgical approach used to transect the GSP. These experiments provide useful parametric data for investigators studying the functional consequences of gustatory nerve transection and regeneration.


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