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Chem. Senses 28: 389-395, 2003
© Oxford University Press 2003

Rats Habituated to Chronic Feeding Restriction Show a Smaller Increase in Olfactory Bulb Reactivity Compared to Newly Fasted Rats

A.F. Apelbaum and M.A. Chaput

Neurosciences et Systèmes Sensoriels, CNRS, Université Claude Bernard, Lyon 1, 50 Avenue Tony Garnier, 69366 Lyon cedex 07, France

Correspondence to be sent to: M.A. Chaput, Neurosciences and Systèmes Sensoriels, CNRS, UMR5020, Université Claude Bernard Lyon 1, 50, avenue Tony Garnier, 69366 Lyon cedex 07, France. e-mail: chaput{at}olfac.univ-lyon1.fr

During the 1970s, the multiunit reactivity of the olfactory bulb to food odor was extensively shown to increase before their usual meal in rats habituated to having a single 2 h daily meal compared to the same rats recorded after their usual meal. More recently, we reported dramatic modifications of mitral cell single-unit reactivity in adult rats following a simple a manipulation of the olfactory environment — exposure to an odor. The present study aimed at testing the hypothesis that a simple behavioral change such as habituation to chronic food restriction may induce profound changes in olfactory bulb responsiveness compared to occasional fasting. We compared mitral cell reactivity in non-fasted rats, in rats fasted during 22 h for the very first time, and in rats habituated during 15 days to a chronic 22 h food restriction. Mitral cell single-unit reactivity was found to increase less in rats habituated to fasting than in newly fasted rats. Indeed, the proportion of mitral cell responses to food and non-food odors was significantly higher in rats habituated to fasting than in non-fasted rats, but lower than in newly fasted rats. The proportion of simple unsynchronized and synchronized responses of 1b and 2b types was also lower in habituated rats whereas the proportion of complex synchronized responses of 4b type increased. This decreased responsiveness in habituated rats, similar to that observed in rats repeatedly exposed for 20 min per day to an odor during six consecutive days in our previous studies, is discussed with respect to olfactory bulb plasticity.

Key words: electrophysiological recordings, fasting, food regimen, mitral cell, odor, plasticity


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E. R. Griff, M. Mafhouz, and M. A. Chaput
Comparison of Identified Mitral and Tufted Cells in Freely Breathing Rats: II. Odor-Evoked Responses
Chem Senses, July 17, 2008; (2008) bjn040v1.
[Abstract] [Full Text] [PDF]


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