Chem. Senses 28: 499-508,
2003
© Oxford University Press 2003
High-resolution Analysis of the Spatio-temporal Activity Patterns in Rat Olfactory Bulb Evoked by Enantiomer Odors
Center for Neural Interfaces, Bioengineering Department, University of Utah, 20S 2030E BPRB Rm #506, Salt Lake City, UT 84112, USA
Correspondence should be sent to: Richard A. Normann, Center for Neural Interfaces, Bioengineering Department, University of Utah, 20S. 2030E. BPRB Rm. #506, Salt Lake City, UT 84112. e-mail: normann{at}utah.edu
Understanding how mammals process olfactory stimuli has motivated the development of tools and techniques which permit the simultaneous study of finely structured spatial and temporal patterns of neural activity. A technique is described that uses an array of 32 penetrating microelectrodes implanted bilaterally into the dorsal aspect of rat olfactory bulb to investigate the responses of mitral and tufted neurons to stimulation with simple enantiomer odor pairs at a number of concentrations. It is shown that stable, simultaneous recordings from up to 49 single- and multi-units can be performed for periods of up to 14 h. We show that such odors evoke unique spatial and fast-temporal activity patterns which may subserve odor discrimination. This technique is extensible to other systems neuroscience investigations of olfactory sensory processing.
Key words: electrophysiology, encoding, ensemble, mitral cells, multielectrode, population
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