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Chem. Senses 28: 751-760, 2003
© Oxford University Press 2003

Time–Intensity Ratings of Nasal Irritation from Carbon Dioxide

Paul M. Wise1, Charles J. Wysocki1 and Tomas Radil2

1 Monell Chemical Senses Center, Philadelphia, PA, USA 2 Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic

Correspondence to be sent to: Dr Paul M. Wise, Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA. e-mail: pwise{at}monell.org

In three experiments, subjects tracked intensity of nasal irritation during sustained presentation of carbon dioxide in the nose. Experiment 1 showed that: (i) functions of peak intensity vs. concentration and latency to first non-zero ratings agreed with published literature, thereby supporting the validity of the technique; (ii) on average, rated intensity peaked ~3–4 s after stimulus-onset and began to fall rapidly thereafter; (iii) large and stable individual differences in temporal dynamics occurred. Experiment 2 replicated experiment 1 with some methodological refinements. In experiment 3, application of the technique revealed that the nose regains sensitivity with very brief (300–500 ms) interruptions in presentation of carbon dioxide. In short: (i) the method developed here provides a temporally fine-grained tool to study the time-course of nasal irritation, and (ii) nasal irritation from carbon dioxide shows relatively rapid temporal dynamics.

Key words: chemesthesis, desensitization, perceptual dynamics, trigeminal


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