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Chem. Senses 28: 761-765, 2003
© Oxford University Press 2003

No Influence of Scopolamine Hydrobromide on Odor Detection Performance of Rats

Richard L. Doty, Ritu Bagla, Robert Misra, Eric Mueller and Kara-Lynne Kerr

Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA

Correspondence to be sent to: Richard L. Doty, Ph.D., Director, Smell and Taste Center, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA. e-mail: doty@mail.med.upenn.edu

Despite speculation that the muscarinic cholinergic antagonist, scopolamine, may influence the olfactory sensitivity of rats, there have been no definitive studies on this point to date. In this study, we examined the influence of a range of doses of scopolamine hydrobromine (namely, 0.10, 0.125, 0.15 and 0.20 mg/kg i.p.) on the odor detection performance of 15 adult male Long–Evans rats to ethyl acetate. Air-dilution olfactometry and a go/no-go operant signal detection task were employed. The drug conditions and a saline control were administered to each animal in an order counterbalanced by Latin squares, with 2 day intervals interspersed between tests. Scopolamine had no significant influence on odor detection performance per se, as measured by percent correct S+ and S– responses and a non-parametric signal detection measure of sensitivity. This is in contrast to the relatively large effects previously observed in the same test paradigm for such drugs as the D-1 agonist SKF 38393 and the D-2 agonist quinpirole. These data suggest that scopolamine has no meaningful influence on a well-practiced odor detection task.

Key words: odor detection, olfaction, psychophysics, rat, scopolamine hydrobromide, sensory threshold, signal detection theory


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