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Chemical Senses 2004 29(6):523-528; doi:10.1093/chemse/bjh055
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Chemical Senses Vol. 29 No. 6 © Oxford University Press 2004; all rights reserved

Female Rats show a Bimodal Preference Response to the Artificial Sweetener Sucralose

Anthony Sclafani and Richard A. Clare

Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA

Correspondence to be sent to: Anthony Sclafani, Department of Psychology, Brooklyn College of CUNY, 2900 Bedford Ave, Brooklyn, NY 11210, USA. e-mail: asclafani{at}gc.cuny.edu

The preference of female Sprague–Dawley rats for sucralose, a non-nutritive sweetener derived from sucrose, was evaluated in 23 h two-bottle tests with water or saccharin. Overall, the rats displayed weak or no preferences for sucralose (0.25–4 g/l) over water but strong preferences for saccharin (0.5–8 g/l) over water and saccharin (1 g/l) over sucralose (0.5 g/l). The rats also preferred a saccharin + sucrose mixture to sucrose, but sucrose to a sucralose + sucrose mixture. There were marked individual differences in sucralose preferences: about half the rats preferred sucralose to water at some concentrations while most remaining rats avoided sucralose. Both subgroups preferred saccharin to sucralose. Sucralose appears to have an aversive off-taste that reduces its palatability to rats.

Key words: artificial sweeteners, individual differences, sex differences, species difference, taste preferences


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