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Chemical Senses 2004 29(6):529-531; doi:10.1093/chemse/bjh057
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Chemical Senses Vol. 29 No. 6 © Oxford University Press 2004; all rights reserved

Dose–Response Relationships in an Olfactory Flux Detector Model Revisited

Karl-Ernst Kaissling1 and Jean-Pierre Rospars2

1 Max-Planck-Institut fuer Verhaltensphysiologie, Seewiesen, 82319 Starnberg, Germany and 2 Unité de Phytopharmacie et Médiateurs chimiques, INRA 78026 Versailles Cedex, France

Correspondence to be sent to: Prof. Dr. Karl-Ernst Kaissling, Max-Planck-Institut fuer Verhaltensphysiologie, Seewiesen, 82319 Starnberg, Germany. E-mail: Kaissling{at}mpi-seewiesen.mpg.de

A simple model of an odorant flux detector including odorant uptake, activation of odorant receptor molecules and enzymatic odorant deactivation can produce different types of static dose–response relationships. Depending on the binding characteristics of the odorant to the receptor molecule and to the deactivating enzyme, the receptor occupation by the odorant as related to the odorant uptake is quasi-hyperbolic, linear or, close to saturation, steeper than linear. In Rospars et al. (2003, Chem. Senses, 28: 509–522) a note contributed by both of us stated erroneously that an equation describing these relationships given previously (Kaissling, 1998, Chem. Senses, 23; 99–111; Kaissling, 2001, Chem. Senses, 26: 125–150) was incorrect. We show here that the difference in equations was due to a simplifying assumption in Rospars et al. (2003) about the deactivating enzyme, we summarize briefly the properties of the correct equation of Kaissling (1998, 2001) and we discuss the relation with the model studied in Rospars et al. (2003).

Key words: chemoreceptors, dose–response relationships, flux detectors, odorant deactivation, pulsed odorant stimulation, receptor occupation modeling


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