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Chemical Senses 2004 29(8):683-692; doi:10.1093/chemse/bjh071
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Chemical Senses Vol. 29 No. 8 © Oxford University Press 2004; all rights reserved

Laryngeal Chemosensory Clusters

Andrea Sbarbati, Flavia Merigo, Donatella Benati, Marco Tizzano, Paolo Bernardi and Francesco Osculati

Department of Morphological-Biomedical Sciences, Human Anatomy and Histology Section, University of Verona, Verona, Italy

Correspondence to be sent to: Professor Andrea Sbarbati, DSMB, Human Anatomy and Histology Section,University of Verona, Medical Faculty, Strada Le Grazie 8, 37134, Verona, Italy. e-mail: andrea.sbarbati{at}univr.it

The expression of molecules involved in the transductory cascade of the sense of taste (TRs, {alpha}-gustducin, PLCß2, IP3R3) has been described in lingual taste buds or in solitary chemoreceptor cells located in different organs. At the laryngeal inlet, immunocytochemical staining at the light and electron microscope levels revealed that {alpha}-gustducin and PLCß2 are mainly localized in chemosensory clusters (CCs), which are multicellular organizations differing from taste buds, being generally composed of two or three chemoreceptor cells. Compared with lingual taste buds, CCs are lower in height and smaller in diameter. In laryngeal CCs, immunocytochemistry using the two antibodies identified a similar cell type which appears rather unlike the {alpha}-gustducin-immunoreactive (IR) and PLCß2-IR cells visible in lingual taste buds. The laryngeal IR cells are shorter than the lingual ones, with poorly developed basal processes and their apical process is shorter and thicker. Some cells show a flask-like shape due to the presence of a large body and the absence of basal processes. CCs lack pores and their delimitation from the surrounding epithelium is poorly evident. The demonstration of the existence of CCs strengthens the hypothesis of a phylogenetic link between gustatory and solitary chemosensory cells.

Key words: gustducin, neuroendocrine cells, phospholipase, taste, taste receptors


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