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Chemical Senses 2005 30(2):127-135; doi:10.1093/chemse/bji008
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Chemical Senses vol. 30 no. 2 © Oxford University Press 2005; all rights reserved.

Cyclic Nucleotide Signaling Mediates an Odorant-suppressible Chloride Conductance in Lobster Olfactory Receptor Neurons

Richard E. Doolin and Barry W. Ache

Whitney Laboratory, Department of Neuroscience, Center for Smell and Taste, and McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA

Correspondence to be sent to: B.W. Ache, Whitney Laboratory, University of Florida, 9505 Ocean Shore Blvd., St. Augustine, FL 32080, USA. e-mail: bwa{at}whitney.ufl.edu

We have previously shown that lobster olfactory receptor neurons (ORNs) express an odorant-suppressible Cl– conductance that modulates the output of the cells. Here, we develop a more complete pharmacological profile of this conductance, showing it is blockable by the Cl– channel blockers DIDS, 9-AC and flufenamic acid, but not by niflumic acid. We then show that a conductance with this pharmacological profile is mediated by cyclic nucleotide signaling. These findings further our understanding of the cellular mechanisms through which odorants can modulate the output of lobster ORNs.

Key words: Cl– conductance, cyclic nucleotide signalling, lobster, olfaction


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