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Chemical Senses Advance Access originally published online on March 30, 2005
Chemical Senses 2005 30(5):377-382; doi:10.1093/chemse/bji032
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Phenylthiocarbamide Produces Conditioned Taste Aversions in Mice

Steven J. St. Johna, Lindsay Poura and John D. Boughter, Jrb

a Department of Psychology, Reed College, Portland, OR 97202, USA and b Department of Anatomy and Neurobiology, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA

Correspondence to be sent to: Steven J. St. John, Department of Psychology, Reed College, Portland, OR 97202, USA. e-mail: stjohns{at}reed.edu

Previous work has demonstrated that SWR/J (SW) mice avoid phenylthiocarbamide (PTC) to a greater degree than C3HeB/FeJ mice in 48 h, two-bottle preference tests given in ascending series. The authors hypothesized, based also on previous work, that SW mice might form a conditioned taste aversion over time due to the toxic properties of PTC. We directly tested this hypothesis by attempting to condition a taste aversion to sucrose by injections of PTC. In experiment 1, PTC was nearly as effective as a strong dose of LiCl in reducing sucrose drinking. In experiment 2, the sucrose aversions were parametrically modified by both sucrose concentration and PTC dose, a hallmark of conditioned taste aversion. We conclude that PTC can cause a conditioned taste aversion and discuss the importance of considering toxic effects of aversive tastants when analyzing behavioral strain differences.

Key words: bitter avoidance, gustatory, strain differences


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