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Chemical Senses Advance Access originally published online on December 21, 2005
Chemical Senses 2006 31(3):197-206; doi:10.1093/chemse/bjj017
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Pulse Stimulation with Odors or IBMX/Forskolin Potentiates Responses in Isolated Olfactory Neurons

Wenling Zhang and Rona J. Delay

Department of Biology, University of Vermont, Burlington, VT 05405, USA

Correspondence to be sent to: Rona J. Delay, 104 Marsh Life Science Building, Department of Biology, University of Vermont, Burlington, VT 05405, USA. e-mail: rona.delay{at}uvm.edu

Many odor responses are mediated by the adenosine 3',5'-cyclic monophosphate (cAMP) pathway in which the cAMP-gated current is amplified by Ca2+-dependent Cl– current. In olfactory neurons, prolonged exposure to odors decreases the odor response and is an adaptive effect. Several studies suggest that odor adaptation is linked to elevated intracellular Ca2+. In the present study, using the perforated configuration of the patch clamp technique, we found that repetitive odor stimulation elicits a potentiation of the subsequent responses in olfactory neurons. This potentiation is mimicked by stimulating the cAMP pathway and does not appear to be related to phosphorylation of ion channels since protein kinase inhibitors could not block it. Our data suggest that local increases in [Ca2+]i via activation of the cAMP pathway mediate the pulse-elicited potentiation. In the first odor application, entry of Ca2+ through cyclic nucleotide–gated channels appears to be buffered. Repetitive stimulation allows local increases in [Ca2+]i, recruiting more Ca2+-dependent Cl– channels with each subsequent odor pulse.

Key words: chloride channel, CNG channel, mudpuppy


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