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Chemical Senses Advance Access originally published online on December 29, 2005
Chemical Senses 2006 31(3):227-235; doi:10.1093/chemse/bjj023
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Temporal Integration in Nasal Lateralization of Ethanol

Paul M. Wise, Thomas M. Canty and Charles J. Wysocki

Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104-3308, USA

Correspondence to be sent to: Paul M. Wise, Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104-3308, USA. e-mail: pwise{at}monell.org

Two experiments examined the trade-off between concentration and stimulus duration in nasal lateralization of n-ethyl alcohol. In nasal lateralization, a common measure of irritation threshold, subjects receive chemical vapor in one nostril and clean air in the other. Subjects try to determine which nostril received the chemical. Within experimental runs, subjects received fixed concentrations (1650–5000 ppm) of ethanol, and duration was varied to find the shortest, lateralizable stimulus. In Experiment 1, a small group of subjects was tested intensively to obtain stable individual data. In Experiment 2, a larger group was studied using more rapid methods. In both cases, subjects could lateralize increasingly weaker concentrations with longer stimulus presentations. Hence integration occurred. However, more than a twofold increase in duration was required to compensate for a twofold decrease in concentration to maintain threshold lateralization. These results suggest that an imperfect, mass-integrator model can describe short-term integration of nasal lateralization of ethanol.

Key words: chemesthesis, dynamics, irritation, trigeminal


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Home page
 Toxicol SciHome page
P. M. Wise, S. E. Toczydlowski, and C. J. Wysocki
Temporal Integration in Nasal Lateralization of Homologous Alcohols
Toxicol. Sci., September 1, 2007; 99(1): 254 - 259.
[Abstract] [Full Text] [PDF]


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