Chemical Senses Advance Access originally published online on July 18, 2006
Chemical Senses 2006 31(7):699-704; doi:10.1093/chemse/bjl011
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Laterality of the Olfactory Event-Related Potential Response
1 Department of Psychology, Umeå University, Umeå, Sweden 2 Department of Head and Neck Surgery, University of California San Diego, San Diego, CA, USA 3 Department of Psychology, San Diego State University, San Diego, CA, USA 4 San Diego State University–University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
Correspondence to be sent to: Claire Murphy, San Diego State University–University of California Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Ct, Suite 101, San Diego, CA 92120-4913, USA. e-mail: cmurphy{at}sciences.sdsu.edu
In experimental practice, odors are commonly applied to only one nostril for recordings of olfactory event-related potentials (OERPs), but the lateralization aspect of the OERP response is unclear regarding both stimulated nostril and cortical topography. The purpose of the present study was to investigate whether stimulated-nostril side affects OERP amplitudes and latencies and whether these potentials indicate lateralization of brain response in healthy, right-handed, young adults. OERPs were recorded from nine electrode sites in response to monorhinal stimulation with amyl acetate in 28 participants. The results showed a general increase in amplitude from frontal to parietal electrode sites (in particular for N1/P3) and generally larger amplitudes on the left hemisphere and midline than on the right hemisphere. There was no main effect of stimulated-nostril side on amplitude. Interactions indicated that N1/P2 amplitude was larger for left- than right-nostril stimulation and larger on the left hemisphere and midline than on the right hemisphere in left-nostril stimulation. No main effect or interactions of stimulated-nostril side over latencies were found and no effects on latencies of sagittal or coronal sites. These findings suggest a general parietal, left-hemisphere predominance in response amplitude to odorous stimulation and imply that either the left or the right nostril may be sufficient for accurate assessment of OERP latency in right-handed, young adults.
Key words: ERP, hemisphere, laterality, OERP, olfaction, smell
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