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Chemical Senses Advance Access originally published online on September 27, 2007
Chemical Senses 2008 33(1):73-78; doi:10.1093/chemse/bjm066
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© The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Thallium Transport and the Evaluation of Olfactory Nerve Connectivity between the Nasal Cavity and Olfactory Bulb

Yayoi Kinoshita1, Hideaki Shiga1, Kohshin Washiyama2, Daisuke Ogawa2, Ryohei Amano2, Makoto Ito1, Toshiaki Tsukatani1, Mitsuru Furukawa1 and Takaki Miwa1

1 Department of Otorhinolaryngology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920, Japan 2 Department of Forefront Medical Technology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920, Japan

Correspondence to be sent to: Hideaki Shiga, Department of Otorhinolaryngology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920, Japan. e-mail: shigah{at}med.kanazawa-u.ac.jp


  Abstract

Little is known regarding how alkali metal ions are transported in the olfactory nerve following their intranasal administration. In this study, we show that an alkali metal ion, thallium is transported in the olfactory nerve fibers to the olfactory bulb in mice. The olfactory nerve fibers of mice were transected on both sides of the body under anesthesia. A double tracer solution (thallium-201, 201Tl; manganese-54, 54Mn) was administered into the nasal cavity the following day. Radioactivity in the olfactory bulb and nasal turbinate was analyzed with gamma spectrometry. Auto radiographic images were obtained from coronal slices of frozen heads of mice administered with 201Tl or 54Mn. The transection of the olfactory nerve fibers was confirmed with a neuronal tracer. The transport of intranasal administered 201Tl/54Mn to the olfactory bulb was significantly reduced by the transection of olfactory nerve fibers. The olfactory nerve transection also significantly inhibited the accumulation of fluoro-ruby in the olfactory bulb. Findings indicate that thallium is transported by the olfactory nerve fibers to the olfactory bulb in mice. The assessment of thallium transport following head injury may provide a new diagnostic method for the evaluation of olfactory nerve injury.

Key words: alkali metal ions, manganese, olfactory transport, thallium

Accepted 31 August 2007


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H. Shiga, Y. Kinoshita, K. Washiyama, D. Ogawa, R. Amano, K. Hirota, T. Tsukatani, M. Furukawa, and T. Miwa
Odor Detection Ability and Thallium-201 Transport in the Olfactory Nerve of Traumatic Olfactory-Impaired Mice
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[Abstract] [Full Text] [PDF]


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