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Chemical Senses Advance Access originally published online on June 4, 2008
Chemical Senses 2008 33(7):633-637; doi:10.1093/chemse/bjn030
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Odor Detection Ability and Thallium-201 Transport in the Olfactory Nerve of Traumatic Olfactory-Impaired Mice

Hideaki Shiga1, Yayoi Kinoshita1, Kohshin Washiyama2, Daisuke Ogawa2, Ryohei Amano2, Kyoko Hirota1, Toshiaki Tsukatani1, Mitsuru Furukawa1 and Takaki Miwa1

1 Department of Otorhinolaryngology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920, Japan 2 Department of Forefront Medical Technology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920, Japan

Correspondence to be sent to: Hideaki Shiga, Department of Otorhinolaryngology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920, Japan. e-mail: shigah{at}med.kanazawa-u.ac.jp


  Abstract

Although olfactory nerve damage is a contributing factor in the diagnosis of posttraumatic olfactory loss, at present, there are no methods to directly assess injury to these nerves. We have shown that following olfactory nerve injury in mice, thallium-201 (201Tl) transport from the nasal cavity to the olfactory bulb decreases. To determine if olfactory function after nerve injury could be assessed with nasal administration of 201Tl, we measured the correlation between odor detection ability (ODA) and the rate of transport of 201Tl in olfactory nerves. Both ODA and 201Tl transport were measured after bilateral olfactory nerve transection for a 4-week period. Cycloheximide solution was used for ODA against tap water. 201Tl transport was measured as the ratio of radioactivity in the nasal cavity and olfactory bulb with gamma spectrometry. There was a significant correlation between ODA and the rate of 201Tl transport in the olfactory nerve. These findings suggest that olfactory function after nerve injury can be objectively evaluated with the nasal administration of 201Tl.

Key words: odor detection, posttraumatic olfactory impairment, thallium-201

Accepted 9 May 2008


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