Chemical Senses Vol. 30 No. suppl 1 © Oxford University
Press 2005; all rights reserved
Taste Receptor Cells Responding with Action Potentials to Taste Stimuli and their Molecular Expression of Taste Related Genes
Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Correspondence to be sent to: Yuzo Ninomiya, e-mail: nino@dent.kyushu-u.ac.jp
Key words: apical taste stimulation, gustatory sensitivity, loose patch recording, mouse fungiform papillae, single cell RT–PCR, taste receptor, taste transduction
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Introduction |
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Recent molecular biological studies have revealed many molecular aspects of taste transduction in receptor cells for each taste categories which are referred to as salty, sweet, sour, bitter and umami in human respectively. (Lindemann, 2001
;
Gilbertson and Boughter, 2003). For
example, ion channels such as ENaC, ASIC and HCN mediate salty and sour taste and
G-protein-coupled receptors such as T1Rs and T2Rs play a key role in sweet, bitter and
umami taste. However, there is little evidence for involvements of these molecules in
taste reception and transduction at the cellular level. It is necessary to examine both
molecular and physiological properties in single taste receptor cell. In this study, by
use of loose patch recording technique combined with single cell multiplex RT–PCR,
we characterized single taste cells by their responses to four |
Materials and methods |
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Results |
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Discussion |
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Acknowledgements |
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