Chemical Senses Vol. 30 No. suppl 1 © Oxford University
Press 2005; all rights reserved
Cloning and Characterization of a Novel mGluR1 Variant from Vallate Papillae that Functions as a Receptor for L-glutamate Stimuli
1 Institute of Life Sciences, Ajinomoto Co., Inc., Kawasaki 210-8681, Japan and 2 Nippon Dental University, Niigata 951-8580, Japan
Correspondence to be sent to: Ana San Gabriel, e-mail: ana_san_gabriel@ajinomoto.com
Key words: L-glutamate, metabotropic, 5' RACE PCR, rat foliate papillae, rat taste receptors, soft palate, Xenopus oocytes
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Introduction |
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Monosodium L-glutamate (MSG) functions as a signal for dietary protein. In the tongue, glutamate binds presumably to taste cell chemoreceptors which, upon being activated, alter the firing rate of innervating sensory nerves. It has just recently been hypothesized that several G protein coupled receptors (GPCR) acted as umami receptors (Chaudhari et al., 2000
;
Li et al., 2002;
Nelson et al., 2002;
Toyono et al., 2003).
However, the receptor mechanism for umami taste perception is still in doubt (Damak et al., 2003;
Zhao et al., 2003). The data
from gustatory nerve recordings, receptor distribution and taste cell
electrophysiological function cannot all be reconciled solely by reference to |
Materials and methods |
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Results |
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Discussion |
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Acknowledgements |
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