Chemical Senses Vol. 30 No. suppl 1 © Oxford University
Press 2005; all rights reserved
Expression of Phospholipase C-ß4 in Rat Circumvallate Taste Buds
Department of Oral Anatomy and Neurobiology, Kyushu Dental College, Kokurakita-ku, Kitakyushu 803-8580, Japan
Correspondence to be sent to: Takashi Toyono, e-mail: toyono@kyu-dent.ac.jp
Key words: mGluR1
, , phospholipase
C-ß, 4, taste bud, umami
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Introduction |
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The heteromer of T1R1 and T1R3 and taste-mGluR4 function as receptors for glutamate (umami) taste sensation (Chaudhari et al., 2000
;
Nelson et al., 2002).
Metabotropic glutamate receptor type 1 (mGluR1) is expressed in taste receptor
cells in rat gustatory papillae (Toyono et
al., 2003). It has been known that mGluR1 couples preferentially
to an -subunit of the Gq family, leading to activation of phospholipase
C-ß (PLC-ß) and the consequent mobilization of intracellular Ca2+
levels in the central nervous system (Hermans and
Challiss, 2001). The inositol tri-phosphate (IP3) pathway is
involved in taste transduction for glutamate in mouse fungiform papilla (Ninomiya et al., 2000). Applications of
glutamate and the mixture of GMP and glutamate to rat taste cells increase intracellular
Ca2+ levels (Lin et al. |
Materials and methods |
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In situ hybridization
Immunohistochemistry
RT–PCR
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Results and discussion |
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