Skip Navigation

Chemical Senses 2005 30(Supplement 1):i31-i32; doi:10.1093/chemse/bjh098
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Kinnamon, S. C.
Right arrow Articles by Delay, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kinnamon, S. C.
Right arrow Articles by Delay, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Chemical Senses Vol. 30 No. suppl 1 © Oxford University Press 2005; all rights reserved

Downstream Signaling Effectors for Umami Taste

Sue C. Kinnamon1,2,2,2, Weihong Lin1,2, Tatsuya Ogura1,2, Collin Ruiz1,2 and Eugene Delay3

1 Department of Biomedical Sciences, Division of Neuroscience, Colorado State University, Fort Collins, CO 80523, USA, 2 Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA and 3 Regis University, Denver, CO, USA

Correspondence to be sent to: Sue C. Kinnamon, e-mail: sue.kinnamon@colostate.edu

Key words: monosodium glutamate, umami, MSG, ribonucleotides, GMP, IMP, gustducin, Ca2+ signaling, TrpM5

The first 10% of the full text of this article appears below.


   Introduction
 
Monosodium glutamate (MSG) elicits a unique taste called umami. A characteristic feature of umami taste is its potentiation by 5'-ribonucleotides (primarily GMP and IMP), which also have an umami taste of their own. Based on recent molecular studies, two putative umami receptors have been identified: a truncated variant of the metabotropic glutamate receptor mGluR4 (taste-mGluR4) (Chaudhari et al., 1996Go, 2000) and the heterodimer, T1R1 + T1R3 (Li et al., 2002Go; Zhao et al., 2003Go). Both of these receptors are expressed in taste cells and both receptors have been expressed in heterologous cells, where they respond to glutamate at taste effective concentrations. The T1R1 + T1R3 heterodimer is potentiated strongly by IMP, when MSG is presented together with the nucleotide. Targeted gene deletion of T1R1 or T1R3 abolishes the synergistic responses of MSG and IMP (Damak et . . . [Full Text of this Article]


   Acknowledgements
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?