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Chemical Senses 2005 30(Supplement 1):i37-i38; doi:10.1093/chemse/bjh101
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Chemical Senses Vol. 30 No. suppl 1 © Oxford University Press 2005; all rights reserved

Communication Routes within the Taste Bud by Neurotransmitters and Neuropeptides

S. Herness, F.-L. Zhao, N. Kaya, T. Shen, S.-G. Lu and Y. Cao

College of Dentistry, Ohio State University, 305 W. 12th Avenue, Columbus, OH 43210, USA

Correspondence to be sent to: Scott Herness, e-mail: herness.1@osu.edu

Key words: gustation, neuromodulation, neurotransmission, sensory processing, sensory transduction, taste

The first 10% of the full text of this article appears below.


   Introduction
 
Taste receptor cells (TRCs) are located throughout the oral cavity, sequestered into morphological structures known as taste buds. These differentiated epithelial cells relay the presence of tastants to the central nervous system via sensory afferent nerves. Only a minority of TRCs within the bud synapse with these nerve fibers. This anatomical finding has lead to the dichotomization of TRCs into ‘true’ TRCs and supporting cells. However, this original conception—that a single TRC is excited by a tastant molecule and releases neurotransmitter onto its postsynaptic afferent nerve fiber—has been undermined by more recent physiological and molecular findings. For example, a single neurotransmitter, as might be expected from this scheme, has not been observed. Rather, there is evidence for at least five neurotransmitters within the mammalian taste bud: glutamate, serotonin, norepinephrine, acetyl choline and . . . [Full Text of this Article]


   Serotonin as a paracrine signaling agent in taste buds
 

   Cholecystokinin as a peptide signaling agent in the taste bud
 

   Conclusions
 

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