Chem. Senses 25: 199-205,
2000
© Oxford University Press 2000
Rewiring the Olfactory Bulb: Changes in Odor Maps following Recovery from Nerve Transection
Department of Physiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298-0551, USA
Correspondence to be sent to: Richard M. Costanzo, Department of Physiology, PO Box 980551, Virginia Commonwealth University, Richmond, VA 23298-0551, USA. e-mail: rcostanz{at}hsc.vcu.edu
Recent studies have shown that axons from olfactory receptor subtypes converge onto glomeruli in fixed positions within the olfactory bulb. Different receptor subtypes project to different glomeruli, forming a spatial distribution of odor information or ‘odor maps’. Olfactory receptor neurons are continuously replaced throughout the life span of an animal, yet they preserve this highly localized mapping of receptor subtypes. In this study we used a transgenic mouse (P2-IRES-tau–lacZ) to map axons from a single receptor subtype (P2 receptors) in order to determine if regenerating axons were able to re-establish the P2 receptor map following nerve transection. Results confirm that P2 receptor axons retain their capacity to grow back to the olfactory bulb and converge onto glomeruli following nerve transection. However, the location and number of convergence sites was significantly altered compared to the control map. This change in the spatial distribution of axons alters the topography of odor mapping and has important implications for the processing of olfactory information. Findings from this study may explain why animals recovering from nerve injury require odor training before odor discrimination is restored. Future studies of olfactory receptor mapping could prove helpful in planning strategies to rewire connections in the brain and to restore function following injury or neurological disease.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Kobayashi and R. M. Costanzo Olfactory Nerve Recovery Following Mild and Severe Injury and the Efficacy of Dexamethasone Treatment Chem Senses, September 1, 2009; 34(7): 573 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kinoshita, H. Shiga, K. Washiyama, D. Ogawa, R. Amano, M. Ito, T. Tsukatani, M. Furukawa, and T. Miwa Thallium Transport and the Evaluation of Olfactory Nerve Connectivity between the Nasal Cavity and Olfactory Bulb Chem Senses, January 1, 2008; 33(1): 73 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. E. Rawson Olfactory Loss in Aging Sci. Aging Knowl. Environ., February 8, 2006; 2006(5): pe6 - pe6. [Abstract] [Full Text]
|
|
|
|
|
|
M. Matsuoka, M. Norita, and R. M. Costanzo A New Surgical Approach to the Study of Vomeronasal System Regeneration Chem Senses, January 1, 2005; 30(suppl_1): i129 - i130. [Full Text] [PDF]
|
|
|
|
|
|
R. M. Costanzo Regeneration and Rewiring the Olfactory Bulb Chem Senses, January 1, 2005; 30(suppl_1): i133 - i134. [Full Text] [PDF]
|
|
|
|
|
|
J. A. S. John and B. Key Axon Mis-targeting in the Olfactory Bulb During Regeneration of Olfactory Neuroepithelium Chem Senses, November 1, 2003; 28(9): 773 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Key and J. St John Axon Navigation in the Mammalian Primary Olfactory Pathway: Where to Next? Chem Senses, March 1, 2002; 27(3): 245 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Potter, C. Zheng, D. S. Koos, P. Feinstein, S. E. Fraser, and P. Mombaerts Structure and Emergence of Specific Olfactory Glomeruli in the Mouse J. Neurosci., December 15, 2001; 21(24): 9713 - 9723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Struble, S. L. Beckman, E. Fesser, and B. P. Nathan Volumetric and Horseradish Peroxidase Tracing Analysis of Rat Olfactory Bulb Following Reversible Olfactory Nerve Lesions Chem Senses, October 1, 2001; 26(8): 971 - 981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Christensen, E. H. Holbrook, R. M. Costanzo, and J. E. Schwob Rhinotopy is Disrupted During the Re-innervation of the Olfactory Bulb that Follows Transection of the Olfactory Nerve Chem Senses, May 1, 2001; 26(4): 359 - 369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Strotmann, S. Conzelmann, A. Beck, P. Feinstein, H. Breer, and P. Mombaerts Local Permutations in the Glomerular Array of the Mouse Olfactory Bulb J. Neurosci., September 15, 2000; 20(18): 6927 - 6938. [Abstract] [Full Text] [PDF]
|
|