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Chem. Senses 28: 603-608, 2003
© Oxford University Press 2003

Expression of bHLH Transcription Factors NSCL1 and NSCL2 in the Mouse Olfactory System

Yuko Suzuki1, Eichi Tsuruga2, Toshihiko Yajima2 and Masako Takeda1

1 Department of Oral Histology 2 Department of Oral Anatomy, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu 061–0293, Japan

Correspondence to be sent to: Yuko Suzuki, Department of Oral Histology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu 061-0293, Japan. e-mail: suzuki{at}hoku-iryo-u.ac.jp

We examined the expression of basic helix–loop–helix transcription factors NSCL1 and NSCL2 in the olfactory epithelium (OE) and the vomeronasal organ (VNO) during development. As detected by in situ hybridization, at embryonic day (E) 10 NSCL1 was weakly expressed in the entire olfactory placodes. From E12 to postnatal day (P) 3, NSCL1 was expressed in olfactory receptor neurons (ORNs) and receptor neurons of the VNO. The expression pattern of NSCL2 was similar to that of NSCL1. By Northern blot analysis, strong expression of NSCL1 was detected in the OE from E12 to P7, but the expression there was low in the adult (P35). NSCL2 mRNA was detected in the E12 and P1 OE, but its level was very low in the P7 and adult OE. The spatial pattern of expression suggests that NSCL1 and NSCL2 contribute to the maturation of ORNs (VNO receptor neurons) or maintenance of their differentiated state. Moreover, the temporal pattern of expression suggests that NSCL1 and NSCL2 may function during development rather than in the adult stage.

Key words: in situ hybridization, NSCL1, NSCL2, olfactory epithelium, vomeronasal organ


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