Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Wise, P. M.
Right arrow Articles by Radil, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wise, P. M.
Right arrow Articles by Radil, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Chem. Senses 28: 751-760, 2003
© Oxford University Press 2003

Time–Intensity Ratings of Nasal Irritation from Carbon Dioxide

Paul M. Wise1, Charles J. Wysocki1 and Tomas Radil2

1 Monell Chemical Senses Center, Philadelphia, PA, USA 2 Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic

Correspondence to be sent to: Dr Paul M. Wise, Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA. e-mail: pwise{at}monell.org

In three experiments, subjects tracked intensity of nasal irritation during sustained presentation of carbon dioxide in the nose. Experiment 1 showed that: (i) functions of peak intensity vs. concentration and latency to first non-zero ratings agreed with published literature, thereby supporting the validity of the technique; (ii) on average, rated intensity peaked ~3–4 s after stimulus-onset and began to fall rapidly thereafter; (iii) large and stable individual differences in temporal dynamics occurred. Experiment 2 replicated experiment 1 with some methodological refinements. In experiment 3, application of the technique revealed that the nose regains sensitivity with very brief (300–500 ms) interruptions in presentation of carbon dioxide. In short: (i) the method developed here provides a temporally fine-grained tool to study the time-course of nasal irritation, and (ii) nasal irritation from carbon dioxide shows relatively rapid temporal dynamics.

Key words: chemesthesis, desensitization, perceptual dynamics, trigeminal


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Toxicol SciHome page
P. M. Wise, S. E. Toczydlowski, and C. J. Wysocki
Temporal Integration in Nasal Lateralization of Homologous Alcohols
Toxicol. Sci., September 1, 2007; 99(1): 254 - 259.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
P. M. Wise, T. M. Canty, and C. J. Wysocki
Temporal Integration in Nasal Lateralization of Ethanol
Chem Senses, March 1, 2006; 31(3): 227 - 235.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
P. M. Wise, T. M. Canty, and C. J. Wysocki
Temporal Integration of Nasal Irritation from Ammonia at Threshold and Supra-threshold Levels
Toxicol. Sci., September 1, 2005; 87(1): 223 - 231.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
P. M. Wise, T. Radil, and C. J. Wysocki
Temporal Integration in Nasal Lateralization and Nasal Detection of Carbon Dioxide
Chem Senses, February 1, 2004; 29(2): 137 - 142.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.