Skip Navigation

Chemical Senses 2004 29(6):483-487; doi:10.1093/chemse/bjh050
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Bieri, S.
Right arrow Articles by Schilling, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bieri, S.
Right arrow Articles by Schilling, B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Chemical Senses Vol. 29 No. 6 © Oxford University Press 2004; all rights reserved

Olfactory Receptor Neuron Profiling using Sandalwood Odorants

Stephan Bieri1, Katherine Monastyrskaia1,2 and Boris Schilling1

1 Givaudan Schweiz AG, Ueberlandstrasse 138, CH-8600 Duebendorf, Switzerland2 Present address: Institute of Anatomy, University of Bern, Buehlstrasse 26, CH-3012 Bern, Switzerland

Correspondence to be sent to: Stephan Bieri, Givaudan Schweiz AG, Ueberlandstrasse 138, CH-8600 Duebendorf, Switzerland. E-mail: stephan.bieri{at}givaudan.com

The mammalian olfactory system can discriminate between volatile molecules with subtle differences in their molecular structures. Efforts in synthetic chemistry have delivered a myriad of smelling compounds of different qualities as well as many molecules with very similar olfactive properties. One important class of molecules in the fragrance industry are sandalwood odorants. Sandalwood oil and four synthetic sandalwood molecules were selected to study the activation profile of endogenous olfactory receptors when exposed to compounds from the same odorant family. Dissociated rat olfactory receptor neurons were exposed to the sandalwood molecules and the receptor activation studied by monitoring fluxes in the internal calcium concentration. Olfactory receptor neurons were identified that were specifically stimulated by sandalwood compounds. These neurons expressed olfactory receptors that can discriminate between sandalwood odorants with slight differences in their molecular structures. This is the first study in which an important class of perfume compounds was analyzed for its ability to activate endogenous olfactory receptors in olfactory receptor neurons.

Key words: olfactory receptor neuron, olfactory receptor, sandalwood, calcium imaging


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
H. Pick, S. Etter, O. Baud, R. Schmauder, L. Bordoli, T. Schwede, and H. Vogel
Dual Activities of Odorants on Olfactory and Nuclear Hormone Receptors
J. Biol. Chem., October 30, 2009; 284(44): 30547 - 30555.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
Y. Furudono, Y. Sone, K. Takizawa, J. Hirono, and T. Sato
Relationship between Peripheral Receptor Code and Perceived Odor Quality
Chem Senses, February 1, 2009; 34(2): 151 - 158.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.