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Chemical Senses Advance Access originally published online on July 27, 2006
Chemical Senses 2006 31(8):739-746; doi:10.1093/chemse/bjl016
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© 2006 The Authors
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Taste Receptor Cells Express Voltage-Dependent Potassium Channels in a Cell Age–Specific Manner

Makoto Ohmoto, Ichiro Matsumoto, Takumi Misaka and Keiko Abe

Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

Correspondence to be sent to: Keiko Abe, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. e-mail: aka7308{at}mail.ecc.u-tokyo.ac.jp

Two voltage-dependent potassium channels, KCNQ1 and KCNH2, are expressed in the taste buds and were identified as strong candidates involved in the repolarization of taste receptor cells expressing phospholipase C-ß2 and TRPM5 (ß2/M5-TRCs). In cell type–specific expression, KCNQ1 was expressed in most taste bud cells, including ß2/M5-TRCs, whereas KCNH2 was expressed in a subset of ß2/M5-TRCs with no correlation with their taste modality, such as sweet or bitter taste reception. Expression of KCNH2 was restricted to young ß2/M5-TRCs. These results suggest that taste bud cells other than ß2/M5-TRCs are depolarized by some stimuli and also that ß2/M5-TRCs have cell age–dependent molecular mechanisms of repolarization.

Key words: cell age, Kv channel, taste bud


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[Abstract] [Full Text] [PDF]


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