Skip Navigation


Chemical Senses Advance Access originally published online on January 17, 2007
Chemical Senses 2007 32(3):255-262; doi:10.1093/chemse/bjl053
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
32/3/255    most recent
bjl053v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Stone, L. M.
Right arrow Articles by Kinnamon, S. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stone, L. M.
Right arrow Articles by Kinnamon, S. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Expression of T1Rs and Gustducin in Palatal Taste Buds of Mice

Leslie M. Stone1,2, Jennell Barrows1,3, Thomas E. Finger1,3 and Sue C. Kinnamon1,2

1 Rocky Mountain Taste and Smell Center, Aurora, CO 80045, USA 2 Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA 3 Department of Cell and Developmental Biology University of Colorado School of Medicine, Aurora, CO 80045, USA

Correspondence to be sent to: Leslie M. Stone, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA. e-mail: leslie.stone-roy{at}colostate.edu


  Abstract

The palatal region of the oral cavity in rodents houses 100–300 taste buds and is particularly sensitive to sweet and umami compounds; yet, few studies have examined the expression patterns of transduction-related molecules in this taste field. We investigated the interrelationships between members of the T1R family and between each T1R and gustducin in palatal taste buds. Similar to lingual taste buds, T1R1 and T1R2 are generally expressed in separate palatal taste cells. In contrast to lingual taste buds, however, T1R2 and T1R3-positive palatal taste cells almost always coexpress gustducin, suggesting that sweet taste transduction in the palate is almost entirely dependent on gustducin. T1R1-positive palate taste cells coexpress gustducin about half the time, suggesting that other G proteins may contribute to the transduction of umami stimuli in this taste field.

Key words: coexpression, gustatory, immunocytochemistry, taste transduction, umami

Accepted 8 December 2006


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
S. C Kinnamon
Umami taste transduction mechanisms
Am. J. Clinical Nutrition, September 1, 2009; 90(3): 753S - 755S.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
H. Miura, A. Nakayama, Y. Shindo, Y. Kusakabe, H. Tomonari, and S. Harada
Expression of Gustducin Overlaps with That of Type III IP3 Receptor in Taste Buds of the Rat Soft Palate
Chem Senses, September 1, 2007; 32(7): 689 - 696.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.