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Chemical Senses 4: 207-214,
© 1979

research-article

Anisole binding protein from olfactory epithelium: evidence for a role in transduction

Stephen J. Goldberg, Jennifer Turpin and Steven Price

Departments of Anatomy and Physiology, Medical College of Virginia, Virginia Commonwealth University Richmond, Virginia 23298, USA

Antibodies were raised against anisole binding protein, a previously reported constituent of olfactory epithelium. Immunoglobulin containing the antibodies is a potent inhibitor of the mouse EOG,less than 1 ng being sufficient to reduce the responses to odorants by about 50%. This suggests that anisole binding protein is a constituent of the apical cell membranes in the olfactory mucosa and that it has a role in olfactory transduction. The fact that the antibodies inhibit responses to various odorants suggests that odor receptor proteins represent a class of membrane proteins in which there is a portion of the molecule common to all and a variable region in which the specificity resides. Thus, immunization with any would result in antibodies directed against all.


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