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Chemical Senses 4: 231-240,
© 1979

research-article

Sodium transport and salt appetite; the effect of DPH on sodium preference and electrolyte balance in rats

A.R. Michell

Department of Medicine, Royal Veterinary College Hawkshead Lane, North Mymms, Hatfield, Herts., UK

The sodium transport hypothesis of salt appetite asserts that drugs affect this appetite according to their effect on sodium transport. Sodium appetite was therefore studied in rats treated with DPH in order to stimulate sodium transport. During 8 days of administration by gastric tube rats increased their sodium intake and preference significantly above control levels involving intubation with vehicle alone. This response was observed in 22 rats offered hypotonic saline (0.5%) and 8 rats offered hypertonic saline (2%), i.e. solutions to which the rats were normally neutral or averse. In rats receiving sodium solely in their food DPH depressed urinary sodium excretion. The results thus support the prediction of the hypothesis, namely, that DPH enhances sodium appetite despite its underlying tendency to cause renal sodium retention.


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