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Chemical Senses Advance Access published online on December 1, 2005
Chemical Senses, doi:10.1093/chemse/bjj004
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted November 2, 2005

Article

Smell Intensity Monitoring Using Metal Oxide Semiconductor Odor Sensors during Intravenous Olfaction Test

Toshiyuki Nakashima 1 *, Kazuki Kidera 2, Junji Miyazaki 2, Yuichiro Kuratomi 2, and Akira Inokuchi 2

1 Department of Otorhinolaryngology-Head & Neck Surgery, Koyanagi Memorial Hospital, Saga 840-2195, Japan; Department of Otorhinolaryngology-Head & Neck Surgery, Faculty of Medicine, Saga University, Saga 849-8501, Japan
2 Department of Otorhinolaryngology-Head & Neck Surgery, Faculty of Medicine, Saga University, Saga 849-8501, Japan

* To whom correspondence should be addressed.
Toshiyuki Nakashima, E-mail: nakashim{at}post.saga-med.ac.jp


  Abstract

The intravenous olfaction test using prosultiamine (PST) solution is simple to perform and has been used clinically in Japan. We monitored intranasal intensity of smell continuously in real time under various conditions of administration using metal oxide semiconductor odor sensors and established an optimal PST injection procedure. In this study, we found that 1) although there was fluctuation in the pattern of intensity of increase in smell in the PST original solution test, the pattern of increase in intranasal smell intensity could be stabilized by prolonging the injection time to 40 s and 2) dilution of PST with physiological saline was effective in preventing angialgia during intravenous injection. It appears that PST administration is best performed by adding 10 ml of saline to 10 mg (2 ml) of PST and injecting the resulting 12-ml solution (6x dilution) and that the best respiratory cycle for testing is once in every 2 s.

Keywords: intranasal smell intensity; intravenous olfaction test; metal oxide semiconductor odor sensor; Portable Odor Meter; prosultiamine.
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