Skip Navigation



Chemical Senses Advance Access published online on November 16, 2006
Chemical Senses, doi:10.1093/chemse/bjj032
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
32/1/99    most recent
bjj032v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Bernstein, I. L.
Right arrow Articles by Koh, M. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bernstein, I. L.
Right arrow Articles by Koh, M. T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted January 13, 2006

Granada Symposium

Molecular Signaling during Taste Aversion Learning

Ilene L. Bernstein 1 * and Ming Teng Koh 2

1 Department of Psychology, University of Washington, Box 351525, Seattle, WA 98195, USA
2 Department Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA

* To whom correspondence should be addressed.
Ilene L. Bernstein, E-mail: ileneb{at}u.washington.edu


  Abstract

Behavioral and neural assessment tools have been used to identify cellular and molecular events that occur during taste aversion acquisition. Studies described here include an assessment of taste information processing and taste-illness association using fos-like immunoreactivity (FLI) to mark populations of cells that react strongly to the taste conditioned stimulus (CS), the illness unconditioned stimulus (US), or the pairing of CS and US. Exposure to a novel, but not a familiar, CS taste (saccharin) was found to induce robust increases in FLI in some, but not all, brain regions previously implicated in taste processing or taste aversion learning. Striking effects of taste novelty on FLI were found in central amygdala (CNA) and insular cortex (IC) but not in basolateral amygdala (BLA), pontine parabrachial nucleus (PBN), or nucleus of the solitary tract (NTS). Of those regions responding to taste novelty, only CNA showed significant elevations in FLI in response to the US, LiCl. In additional studies, FLI was examined after an effective training experience, novel CS-US pairing, and compared with an ineffective one, familiar CS-US pairing. After CS-US pairing, taste novelty modulated FLI in virtually all the regions previously implicated in conditioned taste aversion (CTA) learning, including PBN, CNA, BLA, IC, as well as NTS. Thus, a distributed and interdependent neural CTA circuit is mapped using this method, and the use of localized lesion and inactivation studies promises to further define the functional role of structures within this circuit.

Keywords: amygdala; fos; insular cortex; lithium chloride; novel taste.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
L. Saavedra-Rodriguez, A. Vazquez, H. G. Ortiz-Zuazaga, N. E. Chorna, F. A. Gonzalez, L. Andres, K. Rodriguez, F. Ramirez, A. Rodriguez, and S. P. de Ortiz
Identification of Flap Structure-Specific Endonuclease 1 as a Factor Involved in Long-Term Memory Formation of Aversive Learning
J. Neurosci., May 6, 2009; 29(18): 5726 - 5737.
[Abstract] [Full Text] [PDF]

Home page
 Learn BehavHome page
P. C. HOLLAND
Cognitive versus stimulus-response theories of learning
Learn Behav, August 1, 2008; 36(3): 227 - 241.
[Abstract] [PDF]

Home page
 Learn. Mem.Home page
H. K. Ding, C. M. Teixeira, and P. W. Frankland
Inactivation of the anterior cingulate cortex blocks expression of remote, but not recent, conditioned taste aversion memory
Learn. Mem., April 25, 2008; 15(5): 290 - 293.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
E. C. Kerfoot, I. Agarwal, H. J. Lee, and P. C. Holland
Control of appetitive and aversive taste-reactivity responses by an auditory conditioned stimulus in a devaluation task: A FOS and behavioral analysis
Learn. Mem., August 29, 2007; 14(9): 581 - 589.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.