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Chemical Senses Advance Access first published online on July 27, 2006
This version published online on August 1, 2006
Chemical Senses, doi:10.1093/chemse/bjl016
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted June 29, 2006

Article

Taste Receptor Cells Express Voltage-Dependent Potassium Channels in a Cell Age-Specific Manner

Makoto Ohmoto 1, Ichiro Matsumoto 1, Takumi Misaka 1, and Keiko Abe 1 *

1 Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

* To whom correspondence should be addressed.
Keiko Abe, E-mail: aka7308{at}mail.ecc.u-tokyo.ac.jp


  Abstract

Two voltage-dependent potassium channels, KCNQ1 and KCNH2, are expressed in the taste buds and were identified as strong candidates involved in the repolarization of taste receptor cells expressing phospholipase C-{beta}2 and TRPM5 ({beta}2/M5-TRCs). In cell type-specific expression, KCNQ1 was expressed in most taste bud cells, including {beta}2/M5-TRCs, whereas KCNH2 was expressed in a subset of {beta}2/M5-TRCs with no correlation with their taste modality, such as sweet or bitter taste reception. Expression of KCNH2 was restricted to young {beta}2/M5-TRCs. These results suggest that taste bud cells other than {beta}2/M5-TRCs are depolarized by some stimuli and also that {beta}2/M5-TRCs have cell age-dependent molecular mechanisms of repolarization.

Keywords: cell age; Kv channel; taste bud.

The figures have been changed to color.


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