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Chemical Senses Advance Access published online on October 27, 2006
Chemical Senses, doi:10.1093/chemse/bjl035
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted September 23, 2006

Article

Broad Activation of the Glomerular Layer Enhances Subsequent Olfactory Responses

Cynthia C. Woo 1 *, Edna E. Hingco 1, Brett A. Johnson 1, and Michael Leon 1

1 Department of Neurobiology and Behavior, University of California, Irvine, CA, USA

* To whom correspondence should be addressed.
Cynthia C. Woo, E-mail: cwoo{at}uci.edu


  Abstract

Early olfactory experience with a specific odorant enhances the subsequent response of the glomerular layer of the rat olfactory bulb to that same odorant. Because different odorants activate different glomerular layer regions, it seemed plausible that experience with a large number of odorants might result in enhanced glomerular activation during subsequent exposure to both the previously experienced odorants and the novel odorants evoking activity in regions that overlapped with those previously stimulated by different odorants. To this end, 7 odorants were selected using our glomerular response data archive that together stimulated much of the glomerular layer (alpha-phellandrene, benzaldehyde, L-carvone, decanal, pentanol, santalol, and valeric acid). Young rats were exposed to a different odorant each day for 7 days, and this cycle was repeated 3 times from postnatal days 1-21. The [14C]2-deoxyglucose technique was used to measure neural activity in response to both previously experienced and novel odorants. The 2 novel odorants (alpha-ionone and L-menthone) activate regions of the glomerular layer that overlap with those stimulated by the 7 enrichment odorants. Our results indicate that early experience with multiple odorants results in increased responsiveness both to previously experienced odorants and to novel odorants that stimulate previously activated regions of the bulb.

Keywords: deoxyglucose; enriched environment; mapping; olfaction.
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[Abstract] [Full Text] [PDF]


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