Skip Navigation



Chemical Senses Advance Access published online on August 14, 2008
Chemical Senses, doi:10.1093/chemse/bjn048
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
33/9/839    most recent
bjn048v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Kleene, S. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kleene, S. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

The Electrochemical Basis of Odor Transduction in Vertebrate Olfactory Cilia

Steven J. Kleene

Department of Cancer and Cell Biology, University of Cincinnati, PO Box 670667, Cincinnati, OH, USA

Correspondence to be sent to: Steven J. Kleene, Department of Cancer and Cell Biology, University of Cincinnati, PO Box 670667, 231 Albert Sabin Way, Cincinnati, OH 45267-0667, USA. e-mail: steve{at}syrano.acb.uc.edu


  Abstract

Most vertebrate olfactory receptor neurons share a common G-protein–coupled pathway for transducing the binding of odorant into depolarization. The depolarization involves 2 currents: an influx of cations (including Ca2+) through cyclic nucleotide-gated channels and a secondary efflux of Cl– through Ca2+-gated Cl– channels. The relation between stimulus strength and receptor current shows positive cooperativity that is attributed to the channel properties. This cooperativity amplifies the responses to sufficiently strong stimuli but reduces sensitivity and dynamic range. The odor response is transient, and prolonged or repeated stimulation causes adaptation and desensitization. At least 10 mechanisms may contribute to termination of the response; several of these result from an increase in intraciliary Ca2+. It is not known to what extent regulation of ionic concentrations in the cilium depends on the dendrite and soma. Although many of the major mechanisms have been identified, odor transduction is not well understood at a quantitative level.

Key words: adaptation, chloride channels, cyclic-nucleotide-gated channels, desensitization, olfaction

Accepted 15 July 2008


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JGPHome page
C. Waldeck, K. Vocke, N. Ungerer, S. Frings, and F. Mohrlen
Activation and desensitization of the olfactory cAMP-gated transduction channel: identification of functional modules
J. Gen. Physiol., October 26, 2009; 134(5): 397 - 408.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
J. Reisert and D. Restrepo
Molecular Tuning of Odorant Receptors and Its Implication for Odor Signal Processing
Chem Senses, September 1, 2009; 34(7): 535 - 545.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. J. Kleene
Identifying olfaction's \#8216;other channels'
J. Physiol., September 1, 2009; 587(17): 4135 - 4136.
[Full Text] [PDF]

Home page
 J. Physiol.Home page
S. Pifferi, M. Dibattista, C. Sagheddu, A. Boccaccio, A. Al Qteishat, F. Ghirardi, R. Tirindelli, and A. Menini
Calcium-activated chloride currents in olfactory sensory neurons from mice lacking bestrophin-2
J. Physiol., September 1, 2009; 587(17): 4265 - 4279.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. B. Stephan, E. Y. Shum, S. Hirsh, K. D. Cygnar, J. Reisert, and H. Zhao
ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification
PNAS, July 14, 2009; 106(28): 11776 - 11781.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
R. Tirindelli, M. Dibattista, S. Pifferi, and A. Menini
From Pheromones to Behavior
Physiol Rev, July 1, 2009; 89(3): 921 - 956.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Savigner, P. Duchamp-Viret, X. Grosmaitre, M. Chaput, S. Garcia, M. Ma, and B. Palouzier-Paulignan
Modulation of Spontaneous and Odorant-Evoked Activity of Rat Olfactory Sensory Neurons by Two Anorectic Peptides, Insulin and Leptin
J Neurophysiol, June 1, 2009; 101(6): 2898 - 2906.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
H. Takeuchi, H. Ishida, S. Hikichi, and T. Kurahashi
Mechanism of olfactory masking in the sensory cilia
J. Gen. Physiol., June 1, 2009; 133(6): 583 - 601.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
S. P. Saidu, S.D. Weeraratne, M. Valentine, R. Delay, and J. L. Van Houten
Role of Plasma Membrane Calcium ATPases in Calcium Clearance from Olfactory Sensory Neurons
Chem Senses, May 1, 2009; 34(4): 349 - 358.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Lecoq, P. Tiret, and S. Charpak
Peripheral Adaptation Codes for High Odor Concentration in Glomeruli
J. Neurosci., March 11, 2009; 29(10): 3067 - 3072.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.