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Chemical Senses Advance Access published online on September 26, 2008
Chemical Senses, doi:10.1093/chemse/bjn058
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Using GEFs to Deorphanize Odorant Receptors

B. Malnic and D.S. Kerr

Departamento de Bioquímica, Universidade de São Paulo, C.P. 26077 CEP O5513–970, São Paulo, Brazil

Correspondence to be sent to: B. Malnic, Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, C.P. 26077 CEP O5513–970, São Paulo, Brazil. e-mail: bmalnic@iq.usp.br

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Odorant perception is initiated when odorants activate unique combinations of odorant receptors (ORs) expressed in the cilia of olfactory sensory neurons in the nose (Buck and Axel 1991Go; Malnic et al. 1999Go). One of the greatest challenges in the olfactory science is to correlate ORs with their ligands (to deorphanize the ORs). The determination of OR–ligand pairs should reveal how the OR family is used to generate diverse odorant perceptions (Keller et al. 2007Go, Menashi et al. 2007Go). However, these studies are complicated . . . [Full Text of this Article]


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